To die or to live: the dual role of poly(ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage.

@article{Huang2009ToDO,
  title={To die or to live: the dual role of poly(ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage.},
  author={Qing Huang and Han-ming Shen},
  journal={Autophagy},
  year={2009},
  volume={5 2},
  pages={273-6}
}
Poly(ADP-ribose) polymerase-1 (PARP-1), activated by DNA strand breaks, participates in the DNA repair process physiologically. Excessive activation of PARP-1 mediates necrotic cell death under the status of oxidative stress and DNA damage. However, it remains elusive whether and how PARP-1 activation is involved in autophagy and what is the function of PARP-1-mediated autophagy under oxidative stress and DNA damage. We recently demonstrated that hydrogen peroxide (H(2)O(2)) induces autophagy… CONTINUE READING

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