To die or not to die, does it change the function? Behavior of transgenic mice reveals a role for developmental cell death

@article{RondiReig2002ToDO,
  title={To die or not to die, does it change the function? Behavior of transgenic mice reveals a role for developmental cell death},
  author={L. Rondi-Reig and J. Mariani},
  journal={Brain Research Bulletin},
  year={2002},
  volume={57},
  pages={85-91}
}
  • L. Rondi-Reig, J. Mariani
  • Published 2002
  • Biology, Medicine
  • Brain Research Bulletin
  • In humans, perturbations in the developmental neuronal death leading to an excess of neurons could be associated with developmental neuropsychiatric disorders. Hu-bcl-2 transgenic mice appear to be a valuable tool to study the functional role of developmental programmed cell death. Indeed, the over-expression of the anti-apoptotic gene bcl-2 decreases developmental neuronal death and Hu-bcl-2 mice present supernumerary neurons in several brain regions. A detailed behavioral analysis of these… CONTINUE READING
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