Tmem88a mediates GATA-dependent specification of cardiomyocyte progenitors by restricting WNT signaling.

@article{Novikov2013Tmem88aMG,
  title={Tmem88a mediates GATA-dependent specification of cardiomyocyte progenitors by restricting WNT signaling.},
  author={Natasha D. Novikov and Todd Evans},
  journal={Development},
  year={2013},
  volume={140 18},
  pages={
          3787-98
        }
}
Biphasic control of WNT signaling is essential during cardiogenesis, but how the pathway switches from promoting cardiac mesoderm to restricting cardiomyocyte progenitor fate is unknown. We identified genes expressed in lateral mesoderm that are dysregulated in zebrafish when both gata5 and gata6 are depleted, causing a block to cardiomyocyte specification. This screen identified tmem88a, which is expressed in the early cardiac progenitor field and was previously implicated in WNT modulation by… CONTINUE READING
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