Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation.

@article{Akpinar2005Tmem27AC,
  title={Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation.},
  author={Pinar Akpinar and Satoru Kuwajima and Jan Kr{\"u}tzfeldt and Markus Stoffel},
  journal={Cell metabolism},
  year={2005},
  volume={2 6},
  pages={385-97}
}
The signals and molecular mechanisms that regulate the replication of terminally differentiated beta cells are unknown. Here, we report the identification and characterization of transmembrane protein 27 (Tmem27, collectrin) in pancreatic beta cells. Expression of Tmem27 is reduced in Tcf1(-/-) mice and is increased in islets of mouse models with hypertrophy of the endocrine pancreas. Tmem27 forms dimers and its extracellular domain is glycosylated, cleaved and shed from the plasma membrane of… CONTINUE READING

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Our results identify a pancreatic beta cell transmembrane protein that regulates cell growth of pancreatic islets .
Our results identify a pancreatic beta cell transmembrane protein that regulates cell growth of pancreatic islets .
Our results identify a pancreatic beta cell transmembrane protein that regulates cell growth of pancreatic islets .
Our results identify a pancreatic beta cell transmembrane protein that regulates cell growth of pancreatic islets .
Our results identify a pancreatic beta cell transmembrane protein that regulates cell growth of pancreatic islets .
Our results identify a pancreatic beta cell transmembrane protein that regulates cell growth of pancreatic islets .
Structure of beta Cell of isletAnatomic structure is physical part ofIslets of Langerhans
Our results identify a pancreatic beta cell transmembrane protein that regulates cell growth of pancreatic islets .
Our results identify a pancreatic beta cell transmembrane protein that regulates cell growth of pancreatic islets .
Our results identify a pancreatic beta cell transmembrane protein that regulates cell growth of pancreatic islets .
Our results identify a pancreatic beta cell transmembrane protein that regulates cell growth of pancreatic islets .
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