TmDOTA-: a sensitive probe for MR thermometry in vivo.

@article{Zuo2001TmDOTAAS,
  title={TmDOTA-: a sensitive probe for MR thermometry in vivo.},
  author={Chun S. Zuo and Adeem Mahmood and A Dean Sherry},
  journal={Journal of magnetic resonance},
  year={2001},
  volume={151 1},
  pages={101-6}
}
The lanthanide complex, thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (TmDOTA-), has been investigated as an agent for MR thermometry in vivo. The chemical shifts of the TmDOTA- protons were highly sensitive to temperature at a clinically relevant field strength, yet insensitive to pH and the presence of Ca2+. Given the excellent stability of lanthanide-DOTA complexes and high thermal sensitivity, TmDOTA- is expected to be a good candidate for MR thermometry in vivo.