Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat.

@article{Davis2008Tlr4DS,
  title={Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat.},
  author={Jeremy E. Davis and Nicholas K. Gabler and Jennifer Walker-Daniels and Michael E. Spurlock},
  journal={Obesity},
  year={2008},
  volume={16 6},
  pages={1248-55}
}
Toll-like receptor-4 (Tlr-4), a key pattern recognition receptor involved in innate immune response, is activated by saturated fatty acids (SFAs). To investigate the involvement of this receptor in obesity caused by consumption of diets high in fat, we utilized male Tlr-4-deficient 10ScN mice and 10J controls. Mice were fed either low fat (low-fat control (LFC)), high unsaturated fat (high-fat control (HFC)), or high saturated fat + palmitate (HFP) diets ad libitum for 16 weeks. Relative to the… CONTINUE READING
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