Tli1, a resistance locus for carcinogen-induced T-lymphoma

  title={Tli1, a resistance locus for carcinogen-induced T-lymphoma},
  author={Andrzej Wielowieyski and Laurie A. Brennan and Jan Jongstra},
  journal={Mammalian Genome},
Within 180 days after injection with N-methyl-N-nitrosourea (MNU), 83.5% of AKR/J mice and 37.5% of BALB/cJ mice developed T-lymphoma. The high tumor incidence was a dominant trait, as 93% of MNU-injected F1 mice developed T-lymphoma. A genome screen of 285 MNU-injected F2 mice identified a locus, designated T-lymphoma Induced 1 or Tli1, in a ∼10-cM interval on central Chr 1 between D1Mit87 and D1Mit423 with significant linkage to the incidence of MNU-induced T-lymphoma (P= 0.0004). Injection… CONTINUE READING

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Classical linkage analysis and mapping panels

LM Silver
Mouse Genetics • 1995
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Highly Influenced

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