Tizanidine is mainly metabolized by cytochrome p450 1A2 in vitro.

  title={Tizanidine is mainly metabolized by cytochrome p450 1A2 in vitro.},
  author={Marika T. Granfors and Janne T. Backman and Jouko Laitila and Pertti J Neuvonen},
  journal={British journal of clinical pharmacology},
  volume={57 3},
AIMS To identify the cytochrome p450 (CYP) enzyme(s) that catalyze the metabolism of tizanidine in vitro. METHODS The effect of CYP isoform inhibitors on the elimination of tizanidine was studied using pooled human liver microsomes. The metabolism of the drug by a range of human recombinant CYP isoforms was then investigated. RESULTS Incubation of tizanidine (80 nm) with human liver microsomes resulted in time- and NADPH-dependent substrate consumption with a half-life of 50 min, initial… CONTINUE READING


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