Tityus serrulatus Hypotensins: a new family of peptides from scorpion venom.

@article{VeranoBraga2008TityusSH,
  title={Tityus serrulatus Hypotensins: a new family of peptides from scorpion venom.},
  author={Thiago Verano-Braga and Cibele Rocha-Resende and Diogo Manuel Marques Silva and Danielle A Ianzer and Marie France Martin-Eauclaire and Pierre Edouard Bougis and Maria Elena de Lima and Robson Augusto Souza Santos and Adriano M C Pimenta},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={371 3},
  pages={
          515-20
        }
}
Using a proteomic approach, a new structural family of peptides was put in evidence in the venom of the yellow scorpion Tityus serrulatus. Tityus serrulatus Hypotensins (TsHpt) are random-coiled linear peptides and have a similar bradykinin-potentiating peptide (BPP) amino acid signature. TsHpt-I (2.7kDa), the first member of this family, was able to potentiate the hypotensive effects of bradykinin (BK) in normotensive rats. Using the C-terminal of this peptide as a template, a synthetic analog… CONTINUE READING
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