Corpus ID: 29439071

TitleClinical Studies Animal Infection Models for Vaccine Development

@inproceedings{2016TitleClinicalSA,
  title={TitleClinical Studies Animal Infection Models for Vaccine Development},
  author={},
  year={2016}
}
  • Published 2016
Animal health is considered one of the cornerstones of the “One Health” concept, which includes the interaction and fight against human, animal and wildlife pathogens able to cause disease. Moreover, reduction of antibiotic use is nowadays a compulsory future direction both in animals and humans. In these scenarios, the control of diseases through vaccination is considered of paramount importance. This review aims to discuss the need, design, use and benefit of utilising animal infection models… Expand

Figures and Tables from this paper

References

SHOWING 1-10 OF 39 REFERENCES
Current Status of Veterinary Vaccines
TLDR
Successful veterinary vaccines have been produced against viral, bacterial, protozoal, and multicellular pathogens, which in many ways have led the field in the application and adaptation of novel technologies. Expand
Animal models of yellow fever and their application in clinical research.
TLDR
There are several animal models of YF that replicate various aspects of clinical disease and have provided insight into pathogenic mechanisms of the virus and it is anticipated that these model systems will help facilitate further improvements in the understanding of this virus and in furthering countermeasures to prevent or treat infections. Expand
Overview of the CSIRO Australian Animal Health Laboratory
  • J. Lowenthal
  • Biology, Medicine
  • Journal of Infection and Public Health
  • 2016
TLDR
To combat diseases like MERS, it must take a holistic approach that involves the development of early biomarkers of infection, a suite of treatment options (vaccines, anti-viral drugs and antibody therapeutics) and appropriate animal models to test the safety and efficacy of candidate treatments. Expand
Large animal models for vaccine development and testing.
TLDR
It is demonstrated that much of the success in bringing a new vaccine to market depends on choosing the most appropriate animal model for preclinical testing, and research over the last two decades has highlighted that large animals more accurately predict vaccine outcome in humans than do other models. Expand
HIV vaccine development at the turn of the 21st century.
TLDR
The combined lack of a fully predictive animal model ('mice lie and monkeys exaggerate') and lack of defined markers of immune protection against HIV-1 necessitate that HIV vaccines be tested directly for efficacy in phase IIb/III efficacy trials in human volunteers at risk. Expand
Systems vaccinology: Enabling rational vaccine design with systems biological approaches.
TLDR
If the challenges facing this developing field can be overcome, systems vaccinology promises to empower the identification of early predictive signatures of vaccine response, as well as novel and robust correlates of protection from infection. Expand
Standardization of pathological investigations in the framework of experimental ASFV infections.
TLDR
The presented guidelines establish new approaches to integrate such relevant pathological data with virological and immunological testing, giving support to the global interpretation of the findings in the future experiments of ASFV-related vaccinology and immunology. Expand
The pig: a model for human infectious diseases
TLDR
The numerous advantages of the pig model for infectious disease research and vaccine development are highlighted and a few examples of human microbial infectious diseases for which the use of pigs as animal models has contributed to the acquisition of new knowledge are documented. Expand
Systems vaccinology: Probing humanity’s diverse immune systems with vaccines
  • B. Pulendran
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2014
TLDR
The promise of systems vaccinology is discussed in probing humanity’s diverse immune systems, and in delineating the impact of genes, the environment, and the microbiome on protective immunity induced by vaccination. Expand
The Vaccine Enterprise: Time To Act
TLDR
Record high levels of immunization have been achieved for young children and in March 2005 the Centers for Disease Control and Prevention (CDC) announced that rubella or German measles is no longer a health threat in the United States. Expand
...
1
2
3
4
...