Title Ultrasound targeted microbubble destruction-mediated delivery of a transcription factor decoy inhibits STAT 3 signaling and tumor growth Permalink

@inproceedings{Kopechek2015TitleUT,
  title={Title Ultrasound targeted microbubble destruction-mediated delivery of a transcription factor decoy inhibits STAT 3 signaling and tumor growth Permalink},
  author={Jonathan A. Kopechek and Andrew R. Carson and Charles F McTiernan and Xucai Chen and Bima Hasjim and Linda and Lavery and Malabika Sen and Jennifer R Grandis and Flordeliza S. Villanueva},
  year={2015}
}

• Jonathan A. Kopechek, Andrew R. Carson, +7 authors Flordeliza S. Villanueva
• Published 2015

Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in many cancers where it acts to promote tumor progression. A STAT3-specific transcription factor decoy has been developed to suppress STAT3 downstream signaling, but a delivery strategy is needed to improve clinical translation. Ultrasound-targeted microbubble destruction (UTMD) has been shown to enhance image-guided local delivery of molecular therapeutics to a target site. The objective of this study was… CONTINUE READING

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