Corpus ID: 67775121

Title Radioprotective Effect of Lidocaine on NeurotransmitterAgonist-Induced Secretion in Irradiated Salivary Glands

@inproceedings{Su2013TitleRE,
  title={Title Radioprotective Effect of Lidocaine on NeurotransmitterAgonist-Induced Secretion in Irradiated Salivary Glands},
  author={Yu-xiong Su and Geza A. Benedek and Peter Sieg and Guiqing Liao and Andreas Dendorfer and Birgit Meller and Dirk Rades and Matthias Klinger and Samer George Hakim},
  year={2013}
}
Background: Previously we verified the radioprotective effect of lidocaine on the function and ultrastructure of salivary glands in rabbits. However, the underlying mechanism of lidocaine’s radioprotective effect is unknown. We hypothesized that lidocaine, as a membrane stabilization agent, has a protective effect on intracellular neuroreceptor-mediated signaling and hence can help preserve the secretory function of salivary glands during radiotherapy. Methods and Materials: Rabbits were… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 26 REFERENCES

Enhanced proliferation of acinar and progenitor cells by prophylactic pilocarpine treatment underlies the observed amelioration of radiation injury to parotid glands.

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

On the mechanism of salivary gland radiosensitivity.

VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Receptors in Salivary Glands

VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Regeneration of irradiated salivary glands with stem cell marker expressing cells.

VIEW 1 EXCERPT