Title Page Metabolism of Bupropion by Carbonyl Reductases in Liver and Intestine

Abstract

Bupropion’s metabolism to form hydroxybupropion in the liver by CYP450 2B6 (CYP2B6) has been extensively studied, however, the metabolism to form erythro/threohydrobupropion in the liver and intestine by carbonyl reductases (CR) has not been well characterized. The purpose of this investigation was to compare the relative contribution of the two metabolism… (More)

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