Title Epigenetic inactivation of mir-34 b / c in addition to mir-34 a andDAPK 1 in chronic lymphocytic leukemia


Background: TP53 mutation/deletion is uncommon in chronic lymphocytic leukemia (CLL). We postulated that components of TP53-centered tumor suppressor network, miR-34b/c, in addition to DAPK1 and miR-34a might be inactivated by DNA hypermethylation. Moreover, we tested if miR-34b/c methylation might correlate with miR-203 or miR-124-1 methylation in CLL… (More)

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