Title Aberrant Glycogen Synthase Kinase 3 β Is Involved in Pancreatic CancerCell Invasion and Resistance to Therapy

@inproceedings{Kitano2017TitleAG,
  title={Title Aberrant Glycogen Synthase Kinase 3 β Is Involved in Pancreatic CancerCell Invasion and Resistance to Therapy},
  author={Ayako Kitano and Takeo Shimasaki and Yuri Chikano and Mitsutoshi Nakada and Mayumi Hirose and Tomomi Higashi and Yasuhito Ishigaki and Yoshio Endo and Takahisa Takino and Hiroshi Sato and Yoshimichi Sai and Ken-Ichi Miyamoto and Yoshiharu Motoo and Kazuyuki Kawakami and Toshinari Minamoto},
  year={2017}
}
Background and Purpose: The major obstacles to treatment of pancreatic cancer are the highly invasive capacity and resistance to chemoand radiotherapy. Glycogen synthase kinase 3b (GSK3b) regulates multiple cellular pathways and is implicated in various diseases including cancer. Here we investigate a pathological role for GSK3b in the invasive and treatment resistant phenotype of pancreatic cancer. Methods: Pancreatic cancer cells were examined for GSK3b expression, phosphorylation and… CONTINUE READING

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