Corpus ID: 10054520

Title : Mechanisms of action of anti-TNF-α antibodies in inflammatory bowel disease and their clinical implications : an update

@inproceedings{Eder2016TitleM,
  title={Title : Mechanisms of action of anti-TNF-α antibodies in inflammatory bowel disease and their clinical implications : an update},
  author={P. Eder and K. Linke and J. Witowski},
  year={2016}
}
Mechanisms of action of anti-tumor necrosis factor alpha (anti-TNF-α) antibodies in therapy for inflammatory bowel disease are incompletely understood. Binding of antibodies to transmembrane TNF seems to be crucial for the induction of several cellular responses, including complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity and reverse signaling. However significant, these processes alone do not fully explain the diversity of therapeutic responses seen in different… Expand

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