Title : Elevated Prothrombin Results in Clots with an Altered Fiber Structure : a Possible Mechanism of the Increased Thrombotic Risk Running title : Elevated prothrombin alters clot structure

Individuals with elevated prothrombin levels are at increased risk of venous thrombosis. To understand the mechanism behind this observation, we studied the effect of prothrombin concentration on thrombin generation and fibrin clot structure. The pattern of thrombin generation was directly related to the prothrombin level at all concentrations tested. From… CONTINUE READING