Titin-mediated control of cardiac myofibrillar function.

  title={Titin-mediated control of cardiac myofibrillar function.},
  author={Laurin M. Hanft and M. L. Greaser and K. S. McDonald},
  journal={Archives of biochemistry and biophysics},
According to the Frank-Starling relationship, ventricular pressure or stroke volume increases with end-diastolic volume. This is regulated, in large part, by the sarcomere length (SL) dependent changes in cardiac myofibrillar force, loaded shortening, and power. Consistent with this, both cardiac myofibrillar force and absolute power fall at shorter SL… CONTINUE READING