Titin-based mechanical signalling in normal and failing myocardium.

  title={Titin-based mechanical signalling in normal and failing myocardium.},
  author={Martina Kr{\"u}ger and Wolfgang A Linke},
  journal={Journal of molecular and cellular cardiology},
  volume={46 4},
Nodal points of mechanotransduction are found along the cardiac sarcomere, notably in the Z-disc/I-band and M-band regions. A major integrating component of these mechanosensitive complexes is the giant protein titin, which is anchored at the Z-disc, spans the I-band as an elastic spring and enters the A-band bound to myosin, then reaching all the way to the M-band. Passive-force generation and transmission of stress via the titin filaments may be central to the mechanosensory function of the… CONTINUE READING
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