Titin-based mechanical signalling in normal and failing myocardium.

@article{Krger2009TitinbasedMS,
  title={Titin-based mechanical signalling in normal and failing myocardium.},
  author={Martina Kr{\"u}ger and Wolfgang A Linke},
  journal={Journal of molecular and cellular cardiology},
  year={2009},
  volume={46 4},
  pages={
          490-8
        }
}
Nodal points of mechanotransduction are found along the cardiac sarcomere, notably in the Z-disc/I-band and M-band regions. A major integrating component of these mechanosensitive complexes is the giant protein titin, which is anchored at the Z-disc, spans the I-band as an elastic spring and enters the A-band bound to myosin, then reaching all the way to the M-band. Passive-force generation and transmission of stress via the titin filaments may be central to the mechanosensory function of the… CONTINUE READING
Highly Cited
This paper has 137 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 79 extracted citations

Titin — sensibler Riese der Muskelzellen

BIOspektrum • 2013
View 8 Excerpts
Method Support
Highly Influenced

Acute Heart Failure

Springer International Publishing • 2017

138 Citations

01020'10'12'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 138 citations based on the available data.

See our FAQ for additional information.