Titin and ryanodine receptor antibodies in myasthenia gravis

@article{Skeie2006TitinAR,
  title={Titin and ryanodine receptor antibodies in myasthenia gravis},
  author={Geir Olve Skeie and Johan A. Aarli and Nils Erik Gilhus},
  journal={Acta Neurologica Scandinavica},
  year={2006},
  volume={113}
}
Some myasthenia gravis (MG) patients have antibodies against skeletal muscle antigens in addition to the acetylcholine receptor (AChR). Two major antigens for non‐AchR antibodies in MG are the Ca2+ release channel of the sarcoplasmic reticulum, the ryanodine receptor (RyR) and titin, a gigantic filamentous muscle protein essential for muscle structure, function and development. RyR and titin antibodies are found mainly in thymoma MG patients and in a few late‐onset MG patients and correlate… 
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43 Citations

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  • A. Vincent
  • Biology, Medicine
    Handbook of clinical neurology
  • 2008
Myasthenia Gravis: Autoantibody Specificities and Their Role in MG Management
TLDR
The progress made toward the development of novel sensitive autoantibody detection assays, the identification of new MG autoantigens, and the implications for improved antigen-specific therapeutics are presented.
Serological diagnosis of myasthenia gravis and its clinical significance
TLDR
This work reviews the different methods for detection of various antibodies involved in MG and their sensitivity and specificity and suggests how to adapt the existing therapies to the requirements of each patient.
Autoimmune myasthenia gravis
  • N. Gilhus
  • Medicine, Biology
    Expert review of neurotherapeutics
  • 2009
TLDR
Until curative or antigen-specific therapy become available, the well-established treatment of myasthenia gravis gives good-to-excellent results in most patients, with acceptable quality of life and no increased mortality.
Autoimmune Pathology in Myasthenia Gravis Disease Subtypes Is Governed by Divergent Mechanisms of Immunopathology
TLDR
Three distinct immune mechanisms that describe both the B cell- and autoantibody-mediated pathogenesis of Myasthenia gravis are highlighted by comparing AChR and MuSK MG subtypes.
Autoantibody to dihydropyridine receptor in myasthenia gravis
Heterogeneity in myasthenia gravis: considerations for disease management
TLDR
The management of myasthenia gravis is discussed in relation to its phenotypic and biological heterogeneity, in the light of recent advances in the disease immunopathology, new diagnostic tools and results of clinical trials.
Polygenic disease associations in thymomatous myasthenia gravis.
TLDR
Specific combinations of allelic variants individually associated with MG synergize in predisposing to thymomatous MG and MG with titin antibodies, which seems to be the most important determinant of disease.
Compromised fidelity of B‐cell tolerance checkpoints in AChR and MuSK myasthenia gravis
TLDR
One aspect not previously described is whether defects in central and peripheral tolerance checkpoints, which allow autoreactive B cells to accumulate in the naive repertoire, are found in both or either form of MG.
Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma
TLDR
It is suggested that nmTECs play a significant role in MG pathogenesis via ectopic expression of neuromuscular molecules, which was identified by constructing a comprehensive atlas of thymoma using bulk and single-cell RNA-seq.
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