Titin and ryanodine receptor antibodies in myasthenia gravis

@article{Skeie2006TitinAR,
  title={Titin and ryanodine receptor antibodies in myasthenia gravis},
  author={Geir Olve Skeie and Johan A. Aarli and Nils Erik Gilhus},
  journal={Acta Neurologica Scandinavica},
  year={2006},
  volume={113}
}
Some myasthenia gravis (MG) patients have antibodies against skeletal muscle antigens in addition to the acetylcholine receptor (AChR). Two major antigens for non‐AchR antibodies in MG are the Ca2+ release channel of the sarcoplasmic reticulum, the ryanodine receptor (RyR) and titin, a gigantic filamentous muscle protein essential for muscle structure, function and development. RyR and titin antibodies are found mainly in thymoma MG patients and in a few late‐onset MG patients and correlate… 
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