Titin‐cap associates with, and regulates secretion of, Myostatin

@article{Nicholas2002TitincapAW,
  title={Titin‐cap associates with, and regulates secretion of, Myostatin},
  author={Gina D Nicholas and Mark Thomas and Brett C. Langley and W Greg Somers and Ketan Patel and Charles F Kemp and Mridula Sharma and Ravi Kambadur},
  journal={Journal of Cellular Physiology},
  year={2002},
  volume={193}
}
Myostatin, a secreted growth factor, is a key negative regulator of skeletal muscle growth. To identify modifiers of Myostatin function, we screened for Myostatin interacting proteins. Using a yeast two‐hybrid screen, we identified Titin‐cap (T‐cap) protein as interacting with Myostatin. T‐cap is a sarcomeric protein that binds to the N‐terminal domain of Titin and is a substrate of the titin kinase. Mammalian two‐hybrid studies, in vitro binding assays and protein truncations in the yeast two… 
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TLDR
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It is becoming clearer that besides its conventional role in muscle, myostatin plays a critical role in metabolism, and molecular mechanisms by which hisostatin regulates several key metabolic processes need to be further explored.
Extracellular Regulation of Myostatin: A Molecular Rheostat for Muscle Mass.
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  • Biology
    Immunology, endocrine & metabolic agents in medicinal chemistry
  • 2010
TLDR
The current state of knowledge regarding the regulation of M STN extracellularly by binding proteins is reviewed and the implications of these findings are discussed both with respect to the fundamental physiological role that MSTN plays in regulating tissue homeostasis and with the development of therapeutic agents to combat muscle loss.
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