Titin, a huge, elastic sarcomeric protein with a probable role in morphogenesis
@article{Fulton1991TitinAH, title={Titin, a huge, elastic sarcomeric protein with a probable role in morphogenesis}, author={A. Fulton and W. Isaacs}, journal={BioEssays}, year={1991}, volume={13} }
Titin, the largest protein identified to date (over 1 μm long, almost 3 million daltons in mass) is the third most abundant component of the sarcomere. In the mature myofibril, titin molecules span from M line to Z line, forming a third filament system which provides sarcomeric alignment and elastic recoil. In the developing sarcomere, accumulating evidence from studies both in vivo and in vitro implicates titin as part of a morphogenetic scaffolding, upon which critical events in… CONTINUE READING
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