Titanium dioxide nanoparticles activate the ATM-Chk2 DNA damage response in human dermal fibroblasts.

  title={Titanium dioxide nanoparticles activate the ATM-Chk2 DNA damage response in human dermal fibroblasts.},
  author={Raju Y Prasad and Paul Chastain and Nana Nikolaishvili-Feinberg and Lisa Smeester and William K. Kaufmann and Rebecca C Fry},
  volume={7 6},
The use of nanoparticles in consumer products increases their prevalence in the environment and the potential risk to human health. Although recent studies have shown in vivo and in vitro toxicity of titanium dioxide nanoparticles (nano-TiO2), a more detailed view of the underlying mechanisms of this response needs to be established. Here, the effects of nano-TiO2 on the DNA damage response and DNA replication dynamics were investigated in human dermal fibroblasts. Specifically, the… CONTINUE READING
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