Titanium dioxide aggregating nanoparticles induce autophagy and under-expression of microRNA 21 and 30a in A549 cell line: A comparative study with cobalt(II, III) oxide nanoparticles.

@article{Alinovi2017TitaniumDA,
  title={Titanium dioxide aggregating nanoparticles induce autophagy and under-expression of microRNA 21 and 30a in A549 cell line: A comparative study with cobalt(II, III) oxide nanoparticles.},
  author={Rossella Alinovi and Matteo Goldoni and Silvana Pinelli and Francesca Ravanetti and Maricla Galetti and Giorgio Pelosi and Giuseppe De Palma and Pietro Apostoli and Antonio Cacchioli and Antonio Mutti and Paola Mozzoni},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2017},
  volume={42},
  pages={76-85}
}
The toxicity of TiO2 nanoparticles (NPs) is controversial, while it is widely accepted for Co3O4 NPs. We present a comparative study concerning the uptake of these NPs and their effect on cytoplasmic organelles and autophagy in a human lung carcinoma cell line (A549), including assays on the expression of autophagy-related microRNAs. The NP accumulation… CONTINUE READING