Titanium(IV) complexes: cytotoxicity and cellular uptake of titanium(IV) complexes on caco-2 cell line.

@article{Hernandez2010TitaniumIVCC,
  title={Titanium(IV) complexes: cytotoxicity and cellular uptake of titanium(IV) complexes on caco-2 cell line.},
  author={Rafael Hernandez and J. Rivera Mendez and Jos{\'e} L Lamboy and Madeline Torres and F{\'e}liz R Rom{\'a}n and Enrique Salazar Melendez},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2010},
  volume={24 1},
  pages={
          178-83
        }
}
Replacement of the ancillary ligand in titanocene dichloride by amino acids provides titanocene species with high water solubility. As part of our research efforts in the area of titanium-based antitumor agents, we have investigated the cytotoxic activity of Cp(2)TiCl(2) and three water soluble titanocene-amino acid complexes - [Cp(2)Ti(aa)(2)]Cl(2) (aa=L-cysteine, L-methionine, and D-penicillamine) and one water soluble coordination compound, [Ti(4)(maltolato)(8)(micro-O)(4)] on the human… CONTINUE READING
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