Titanium(IV)-promoted Mukaiyama aldol-Prins cyclizations.


[reaction: see text] A new version of the Mukaiyama aldol-Prins (MAP) cyclization has been developed. Unsaturated enol ethers such as 3 were found to couple with aldehydes in the presence of TiBr(4) to give 4-bromotetrahydropyran products. This cascade reaction sequence leads to the formation of two new carbon-carbon bonds, a ring, and three new stereogenic… (More)


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.