TissueTargeting in Cancer : eIF 4 E ’ sTale 55

In this issue of Clinical Cancer Research, Ko and colleagues (1) report that they have developed a novel strategy to specifically target eIF4E activity in ovarian tissue by fusing 4EBP1 peptides to an agonist of the gonadotropin-releasing hormone (GnRH). The levels and activity of the eukaryotic translation initiation factor eIF4E are elevated in many human… (More)