Tissue uptake study and photodynamic therapy of melanoma-bearing mice with a nontoxic, effective chlorin.

@article{Dbrowski2011TissueUS,
  title={Tissue uptake study and photodynamic therapy of melanoma-bearing mice with a nontoxic, effective chlorin.},
  author={Janusz M Dąbrowski and Martyna Krzykawska and Luis G Arnaut and Mariette M Pereira and Carlos J P Monteiro and S{\'e}rgio Sim{\~o}es and Krystyna M. Urbanska and Grazyna Stochel},
  journal={ChemMedChem},
  year={2011},
  volume={6 9},
  pages={1715-26}
}
Chlorins have intense red absorptions and high tumor affinities that make them interesting candidates for photodynamic therapy (PDT) of cancer. This paper reports cytotoxicity, phototoxicity, in vitro cellular uptake, and in vivo biodistribution and PDT efficacy of a synthetic chlorin derivative (TCPCSO₃H) towards Cloudman melanoma cells (S91). No cytotoxic… CONTINUE READING