Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function.

@article{Samson2008TissuetypePA,
  title={Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function.},
  author={Andre L Samson and Simon T. Nevin and David R. Croucher and Be'eri Niego and Philip B Daniel and Thomas Werner Weiss and Eliza Moreno and Denis Monard and Daniel A Lawrence and Robert L Medcalf},
  journal={Journal of neurochemistry},
  year={2008},
  volume={107 4},
  pages={1091-101}
}
Glutamate is the main excitatory neurotransmitter of the CNS. Tissue-type plasminogen activator (tPA) is recognized as a modulator of glutamatergic neurotransmission. This attribute is exemplified by its ability to potentiate calcium signaling following activation of the glutamate-binding NMDA receptor (NMDAR). It has been hypothesized that tPA can directly cleave the NR1 subunit of the NMDAR and thereby potentiate NMDA-induced calcium influx. In contrast, here we show that this increase in… CONTINUE READING