Tissue-type plasminogen activator regulates the neuronal uptake of glucose in the ischemic brain.

@article{Wu2012TissuetypePA,
  title={Tissue-type plasminogen activator regulates the neuronal uptake of glucose in the ischemic brain.},
  author={Fang Wu and Jialing Wu and Andrew D Nicholson and Ramiro Echeverry and Woldeab B Haile and Marcela Catano and Jie An and Andrew K Lee and Duc M Duong and Eric B Dammer and Nicholas T Seyfried and Frank Chi-Hung Tong and John R. Votaw and Robert L Medcalf and Manuel Yepes},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 29},
  pages={9848-58}
}
The ability to sense and adapt to hypoxic conditions plays a pivotal role in neuronal survival. Hypoxia induces the release of tissue-type plasminogen activator (tPA) from cerebral cortical neurons. We found that the release of neuronal tPA or treatment with recombinant tPA promotes cell survival in cerebral cortical neurons previously exposed to hypoxic conditions in vitro or experimental cerebral ischemia in vivo. Our studies using liquid chromatography and tandem mass spectrometry revealed… CONTINUE READING