Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit.

@article{Polavarapu2007TissuetypePA,
  title={Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit.},
  author={Rohini Polavarapu and Mar{\'i}a Carolina G{\'o}ngora and Hong Yi and Sripriya Ranganthan and Daniel A Lawrence and Dudley K Strickland and Manuel Yepes},
  journal={Blood},
  year={2007},
  volume={109 8},
  pages={3270-8}
}
The low-density lipoprotein receptor-related protein (LRP) is a member of the LDL receptor gene family that binds several ligands, including tissue-type plasminogen activator (tPA). tPA is found in blood, where its primary function is as a thrombolytic enzyme, and in the central nervous system where it mediates events associated with cell death. Cerebral ischemia induces changes in the neurovascular unit (NVU) that result in brain edema. We investigated whether the interaction between tPA and… CONTINUE READING