Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic

@article{Yepes2009TissuetypePA,
  title={Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic},
  author={Manuel Yepes and Beno{\^i}t Denis Roussel and Carine Ali and Denis Vivien},
  journal={Trends in Neurosciences},
  year={2009},
  volume={32},
  pages={48-55}
}
Thrombolysis with tissue-type plasminogen activator (tPA) is used for the treatment of patients with acute ischemic stroke. However, a growing body of evidence indicates that, besides the unquestionable benefit from its thrombolytic activity, tPA also has a deleterious effect on the ischemic brain including cytotoxicity and increased permeability of the neurovascular unit with the development of cerebral edema. Because an increasing number of acute stroke patients are treated with tPA, it is… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 132 CITATIONS, ESTIMATED 55% COVERAGE

Alteplase: a review of its use in the management of acute ischaemic stroke.

  • CNS drugs
  • 2012
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Microglial low-density lipoprotein receptor-related protein 1 mediates the effect of tissue-type plasminogen activator on matrix metalloproteinase-9 activity in the ischemic brain.

  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2009
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2008
2019

CITATION STATISTICS

  • 10 Highly Influenced Citations

  • Averaged 7 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 77 REFERENCES

Development of a metropolitan matrix of primary stroke centers : the Phoenix experience

A. V. Alexandrov
  • 2008

Key role of tissue plasminogen activator in neurovascular coupling.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2008

Methodology of the Interventional Management of Stroke III Trial

P Khatri
  • Int. J. Stroke
  • 2008

Phoenix Operation Stroke Executive Committee (2008) Development of a metropolitan matrix of primary stroke centers: the Phoenix experience

Demaerschalk, B.M
  • Stroke
  • 2008

Similar Papers

Loading similar papers…