Tissue-type plasminogen activator deficiency attenuates peritoneal fibrosis in mice.

@article{Kurata2009TissuetypePA,
  title={Tissue-type plasminogen activator deficiency attenuates peritoneal fibrosis in mice.},
  author={Kei Kurata and Shoichi Maruyama and Sawako Kato and Waichi Sato and Jun-ichiro Yamamoto and Takenori Ozaki and Atsumi Nitta and Toshitaka Nabeshima and Yoshiki Morita and Masashi Mizuno and Yasuhiko Ito and Yukio Yuzawa and Seiichi Matsuo},
  journal={American journal of physiology. Renal physiology},
  year={2009},
  volume={297 6},
  pages={
          F1510-7
        }
}
Peritoneal fibrosis (PF) is an important complication of peritoneal dialysis therapy. The present study was performed to examine the mechanisms of PF in view of the plasminogen activator (PA)/plasmin/matrix metalloproteinase (MMP) cascade. PF was induced in tissue-type PA (tPA) deficient mice and wild-type mice by intraperitoneal injection of chlorhexidine gluconate. Mice were killed on day 21, and tissue samples were taken. Histopathological studies were performed. Plasmin activity… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

Matrix Metalloproteinases Cause Peritoneal Injury in Peritoneal Dialysis

VIEW 5 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Noninvasive monitoring of pulmonary fibrosis by targeting matrix metalloproteinases (MMPs).

Yan Cai, Lei Zhu, +4 authors Xiaoyuan Chen
  • Molecular pharmaceutics
  • 2013

Twist: a new player in the epithelial-mesenchymal transition of the peritoneal mesothelial cells.

  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2012
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 39 REFERENCES

Preservation of peritoneal morphology and function by pentoxifylline in a rat model of peritoneal dialysis: molecular studies.

  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2008
VIEW 1 EXCERPT

Inhibitory effects of matrix metalloproteinase inhibitor ONO-4817 on morphological alterations in chlorhexidine gluconate-induced peritoneal sclerosis rats.

  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2007
VIEW 2 EXCERPTS

Intrarenal administration of recombinant human soluble thrombomodulin ameliorates ischaemic acute renal failure.

  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2007
VIEW 1 EXCERPT