Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes.

@article{Nestor2012TissueTI,
  title={Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes.},
  author={Colm E. Nestor and Raffaele Ottaviano and James P. Reddington and Duncan Sproul and Diana Reinhardt and Donncha S. Dunican and Elad Katz and J. M. Dixon and D J Harrison and Richard R. Meehan},
  journal={Genome research},
  year={2012},
  volume={22 3},
  pages={467-77}
}
The discovery of substantial amounts of 5-hydroxymethylcytosine (5hmC), formed by the oxidation of 5-methylcytosine (5mC), in various mouse tissues and human embryonic stem (ES) cells has necessitated a reevaluation of our knowledge of 5mC/5hmC patterns and functions in mammalian cells. Here, we investigate the tissue specificity of both the global levels and locus-specific distribution of 5hmC in several human tissues and cell lines. We find that global 5hmC content of normal human tissues is… CONTINUE READING

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Active DNA demethylation: many roads lead to Rome

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