Tissue-transplant fusion and vascularization of myocardial microtissues and macrotissues implanted into chicken embryos and rats.

@article{Kelm2006TissuetransplantFA,
  title={Tissue-transplant fusion and vascularization of myocardial microtissues and macrotissues implanted into chicken embryos and rats.},
  author={Jens Maria Kelm and Valentin Djonov and Simon P Hoerstrup and Christina Irene G{\"u}nter and Lars M Ittner and Frauke Greve and Andreas Hierlemann and Carlota Diaz Sanchez-Bustamante and J. -C. Perriard and Elisabeth Ehler and Martin Fussenegger},
  journal={Tissue engineering},
  year={2006},
  volume={12 9},
  pages={2541-53}
}
Cell-based therapies and tissue engineering initiatives are gathering clinical momentum for next-generation treatment of tissue deficiencies. By using gravity-enforced self-assembly of monodispersed primary cells, we have produced adult and neonatal rat cardiomyocyte-based myocardial microtissues that could optionally be vascularized following coating with human umbilical vein endothelial cells (HUVECs). Within myocardial microtissues, individual cardiomyocytes showed native-like cell shape and… CONTINUE READING

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