Tissue transglutaminase is an important player at the surface of human endothelial cells: evidence for its externalization and its colocalization with the beta(1) integrin.

@article{Gaudry1999TissueTI,
  title={Tissue transglutaminase is an important player at the surface of human endothelial cells: evidence for its externalization and its colocalization with the beta(1) integrin.},
  author={Claire A. Gaudry and Elisabetta Verderio and Richard A Jones and Christina B Smith and M. F. Griffin},
  journal={Experimental cell research},
  year={1999},
  volume={252 1},
  pages={104-13}
}
We recently reported [J. Cell Sci. 110, 2461-2472 (1997)] that reduced expression of tissue transglutaminase (tTgase, type II) in human endothelial cell line ECV304 led to impaired cell spreading and adhesion; however, there is no immunocytochemical evidence for its presence and specific location at the surface of these cells. In this report we have stably transfected the same cell line with the cDNA for human tTgase which has been tagged at the C-terminus of the encoded protein with a 12-amino… CONTINUE READING

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