Tissue transglutaminase expression promotes castration-resistant phenotype and transcriptional repression of androgen receptor.

@article{Han2014TissueTE,
  title={Tissue transglutaminase expression promotes castration-resistant phenotype and transcriptional repression of androgen receptor.},
  author={Amy Lee Han and S. B. Vinay Kumar and Jansina Y. Fok and Amit Kumar Tyagi and Kapil Mehta},
  journal={European journal of cancer},
  year={2014},
  volume={50 9},
  pages={1685-96}
}
Many studies have supported a role for inflammation in prostate tumour growth. However, the contribution of inflammation to the development of castration-resistant prostate cancer remains largely unknown. Based on observations that aberrant expression of the proinflammatory protein tissue transglutaminase (TG2) is associated with development of drug resistance and metastatic phenotype in multiple cancer types, we determined TG2 expression in prostate cancer cells. Herein we report that human… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS
8 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…