Tissue transglutaminase expression in human breast cancer.

  title={Tissue transglutaminase expression in human breast cancer.},
  author={J M Hettasch and Nicholas Bandarenko and James L. Burchette and T S Lai and Jeffrey R. Marks and Zishan A. Haroon and Kevin Peters and Mark W. Dewhirst and James Dirk Iglehart and Charles S. Greenberg},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  volume={75 5},
Tissue transglutaminase (tTG) is postulated to play a role in apoptosis, cell adhesion, metastasis, and extracellular matrix (ECM) assembly. In this study, the distribution and expression of tissue transglutaminase was investigated in normal human mammary tissue and in intraductal and invasive human breast cancer by immunohistochemistry and in situ hybridization. Frozen and formalin-fixed paraffin-embedded sections of normal, intraductal, and invasive human breast carcinoma were examined with… CONTINUE READING
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