Tissue transglutaminase does not affect fibrotic matrix stability or regression of liver fibrosis in mice.

@article{Popov2011TissueTD,
  title={Tissue transglutaminase does not affect fibrotic matrix stability or regression of liver fibrosis in mice.},
  author={Yury V Popov and Deanna Y. Sverdlov and Anisha K. Sharma and K. Ramakrishnan Bhaskar and Shaoyong Li and Tobias L. Freitag and James Chun-Yin Lee and Walburga Dieterich and Gerry Melino and Detlef B Schuppan},
  journal={Gastroenterology},
  year={2011},
  volume={140 5},
  pages={1642-52}
}
BACKGROUND & AIMS The ubiquitous cross-linking enzyme tissue transglutaminase (TG2) has been implicated in irreversible collagen stabilization in liver fibrosis, although functional evidence is lacking. We studied the contribution of TG2 to hepatic fibrotic matrix stability, as well as liver fibrosis progression and regression in TG2-deficient mice. METHODS Advanced liver fibrosis was induced by carbon tetrachloride or thioacetamide in TG2(-/-) mice and their wild-type littermates to study… CONTINUE READING
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