Tissue transglutaminase (TG2) acting as G protein protects hepatocytes against Fas-mediated cell death in mice.

@article{Sarang2005TissueT,
  title={Tissue transglutaminase (TG2) acting as G protein protects hepatocytes against Fas-mediated cell death in mice.},
  author={Zsolt Sarang and Peter J Molnar and Tam{\'a}s N{\'e}meth and Szabolcs Gomba and Tam{\'a}s Kardon and Gerry Melino and Susanna Cotecchia and L{\'a}szl{\'o} F{\'e}s{\"u}s and Zsuzsa Szondy},
  journal={Hepatology},
  year={2005},
  volume={42 3},
  pages={578-87}
}
Tissue transglutaminase (TG2) is a protein cross-linking enzyme known to be expressed by hepatocytes and to be induced during the in vivo hepatic apoptosis program. TG2 is also a G protein that mediates intracellular signaling by the alpha-1b-adrenergic receptor (AR) in liver cells. Fas/Fas ligand interaction plays a crucial role in various liver diseases, and administration of agonistic anti-Fas antibodies to mice causes both disseminated endothelial cell apoptosis and fulminant hepatic… CONTINUE READING