Tissue transformation into bone in vivo. A potential practical application.

@article{Khouri1991TissueTI,
  title={Tissue transformation into bone in vivo. A potential practical application.},
  author={Roger Karl Khouri and B Koudsi and Honey Reddi},
  journal={JAMA},
  year={1991},
  volume={266 14},
  pages={
          1953-5
        }
}
The transformation of mesenchymal tissue, such as muscle, into cartilage and bone can be induced by the recently purified osteoinductive factor, osteogenin, and by its parent substratum, demineralized bone matrix. We investigated the possibility of transforming readily available muscle flaps into vascularized bone grafts of various shapes that could be used as skeletal replacement parts. In a rat experimental model, thigh adductor muscle island flaps were placed inside bivalved silicone rubber… CONTINUE READING
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