Tissue targeting of angiotensin peptides.

  title={Tissue targeting of angiotensin peptides.},
  author={Danielle Methot and Margot C. Lapointe and Rhian M Touyz and Xiao Ping Yang and Oscar A. Carretero and Christian F. Deschepper and Ernesto L Schiffrin and Ga{\'e}tan Thibault and Timothy L. Reudelhuber},
  journal={The Journal of biological chemistry},
  volume={272 20},
Angiotensin II (Ang II) is an octapeptide generated by the sequential proteolytic action of renin and angiotensin converting enzyme on the glycoprotein angiotensinogen. While numerous mammalian tissues have been shown to express some or all of the components of the renin-angiotensin system (RAS), the function of most of these tissue RAS remains a matter of conjecture. To test for tissue-specific functions of Ang II and as an alternative to co-expressing all the components of RAS, we have… CONTINUE READING


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