Tissue specificity of the epidermal chalones.

  title={Tissue specificity of the epidermal chalones.},
  author={Ole Nome},
  journal={Virchows Archiv. B, Cell pathology},
  volume={19 1},
  • Ole Nome
  • Published 1975 in Virchows Archiv. B, Cell pathology
An increasing body of evidence indicates that the rate of cell renewal in labile and stable cell populations is regulated according to a negative feedback principle. Water extracts of such tissues contain mitosis-inhibiting substances (chalones) that probably represent the chemical signals in these cell populations. Tissue specificity is one of the theoretical prereguisites of the chalones but has not been proven in many cases. The present study is an attempt to evaluate the tissue specificity… CONTINUE READING