Tissue specificity of insulin resistance in humans: fat in the liver rather than muscle is associated with features of the metabolic syndrome

@article{Kotronen2007TissueSO,
  title={Tissue specificity of insulin resistance in humans: fat in the liver rather than muscle is associated with features of the metabolic syndrome},
  author={Anna Kotronen and Anneli Sepp{\"a}l{\"a}-Lindroos and Robert Bergholm and Hannele Yki-J{\"a}rvinen},
  journal={Diabetologia},
  year={2007},
  volume={51},
  pages={130-138}
}
The aim of this study was to investigate whether intrahepatic and intramyocellular fat are related to insulin resistance in these respective tissues or to the metabolic syndrome. Hepatic (insulin 1.8 pmol kg−1 min−1 combined with [3-3H]glucose) and muscle (insulin 6.0 pmol kg−1 min−1) insulin sensitivity were measured on separate occasions in 45 non-diabetic men (age 42 ± 1 years, BMI 26.2 ± 0.6 kg/m2) using the euglycaemic–hyperinsulinaemic clamp. Liver fat and intramyocellular lipid (IMCL… CONTINUE READING