Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase.

@article{Defer2000TissueSA,
  title={Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase.},
  author={Nicole Defer and M. Best-Belpomme and Jacques Hanoune},
  journal={American journal of physiology. Renal physiology},
  year={2000},
  volume={279 3},
  pages={
          F400-16
        }
}
The present review focuses on the potential physiological regulations involving different isoforms of adenylyl cyclase (AC), the enzymatic activity responsible for the synthesis of cAMP from ATP. Depending on the properties and the relative level of the isoforms expressed in a tissue or a cell type at a specific time, extracellular signals received by the G protein-coupled receptors can be differently integrated. We report here on various aspects of such regulations, emphasizing the role of Ca… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 200 REFERENCES

The 5'-flanking region of the mouse adenylyl cyclase type VIII gene imparts tissue-specific expression in transgenic mice.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1999
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

Adenylyl cyclase 6 is selectively regulated by protein kinase A phosphorylation in a region involved in Galphas stimulation.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1997
VIEW 14 EXCERPTS
HIGHLY INFLUENTIAL

Regulation of adenylyl cyclase by protein kinase A.

  • The Journal of biological chemistry
  • 1995
VIEW 13 EXCERPTS
HIGHLY INFLUENTIAL

G protein regulation of adenylate cyclase.

  • Trends in pharmacological sciences
  • 1999
VIEW 15 EXCERPTS
HIGHLY INFLUENTIAL

Role of protein kinase C in ethanol-induced activation of adenylyl cyclase.

  • Alcoholism, clinical and experimental research
  • 1999
VIEW 13 EXCERPTS
HIGHLY INFLUENTIAL

Ca(21)sensitive adenylyl cyclases

DM Cooper, JW Karpen, KA Fagan, NE. Mons
  • Adv Second Messenger Phosphoprotein Res
  • 1998
VIEW 15 EXCERPTS
HIGHLY INFLUENTIAL