Tissue-specific variation in glycation of proteins in diabetes: evidence for a functional role of amadoriase enzymes.

@article{Brown2005TissuespecificVI,
  title={Tissue-specific variation in glycation of proteins in diabetes: evidence for a functional role of amadoriase enzymes.},
  author={Sarah M Brown and Della M Smith and Nadja Alt and Suzanne R. Thorpe and John W. Baynes},
  journal={Annals of the New York Academy of Sciences},
  year={2005},
  volume={1043},
  pages={817-23}
}
The Amadori product fructoselysine (FL), an intermediate in the formation of many advanced glycation end products, may be deglycated by various pathways. These include spontaneous chemical degradation or enzymatic deglycation by amadoriases. This study was designed to compare changes in FL in various tissues in response to changes in glycemia, thereby testing tissue-specific deglycation. FL content in skin collagen, red cell hemoglobin, and total muscle, liver, and brain protein was analyzed by… CONTINUE READING

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