Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130.

@article{Dannenberg2004TissuespecificTS,
  title={Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130.},
  author={J. G. Dannenberg and Leontine S. Schuijff and Marleen Dekker and Martin A van der Valk and Hein te Riele},
  journal={Genes & development},
  year={2004},
  volume={18 23},
  pages={2952-62}
}
The retinoblastoma gene family consists of three genes: RB, p107, and p130. While loss of pRB causes retinoblastoma in humans and pituitary gland tumors in mice, tumorigenesis in other tissues may be suppressed by p107 and p130. To test this hypothesis, we have generated chimeric mice from embryonic stem cells carrying compound loss-of-function mutations in the Rb gene family. We found that Rb/p107- and Rb/p130-deficient mice were highly cancer prone. We conclude that in a variety of tissues… CONTINUE READING

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