Tissue-specific transgenic and knockout mice.

@article{Porret2006TissuespecificTA,
  title={Tissue-specific transgenic and knockout mice.},
  author={Andr{\'e}e Porret and Anne-Marie M{\'e}rillat and Sabrina Guichard and Friedrich Beermann and Edith Hummler},
  journal={Methods in molecular biology},
  year={2006},
  volume={337},
  pages={
          185-205
        }
}
Analysis of genetically engineered mice is crucial for our understanding of the in vivo function of genes and proteins in the whole organism. This includes inactivation of a gene or the generation of specific mutations. The development of knockout and transgenic technologies in the mouse, therefore, represents a powerful tool for elucidating gene function, for modeling of human diseases, and potentially for the evaluation of drugs. In particular, conditional gene targeting applying the Cre/loxP… CONTINUE READING
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