Tissue-specific targeting of the pthrp gene: the generation of mice with floxed alleles.

@article{He2001TissuespecificTO,
  title={Tissue-specific targeting of the pthrp gene: the generation of mice with floxed alleles.},
  author={Bo-Wen He and Ron A Deckelbaum and De-nian Miao and Mark Bagnoli Barton L. Lipman and Martin Pollak and David Goltzman and Andrew C Karaplis},
  journal={Endocrinology},
  year={2001},
  volume={142 5},
  pages={2070-7}
}
PTH-related peptide (PTHrP) has been implicated in a variety of developmental and homeostatic processes. Although mice homozygous for the targeted disruption of the Pthrp gene have greatly expanded our capacity to investigate the developmental roles of the protein, the perinatal lethality of these animals has severely hindered the analysis of Pthrp's postnatal physiological effects. To overcome this obstacle, we have generated mice homozygous for a floxed Pthrp allele, i.e. two loxP sites… CONTINUE READING

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