Tissue-specific synthesis and oxidative metabolism of estrogens.

@article{Jefcoate2000TissuespecificSA,
  title={Tissue-specific synthesis and oxidative metabolism of estrogens.},
  author={Colin R Jefcoate and Joachim G. Liehr and R. J. Santen and Thomas R. Sutter and James D. Yager and Wei Yue and Steven J. Santner and Rajeshwar R Tekmal and Laurence M. Demers and Robert J. Pauley and Frederick Naftolin and Gil Mor and Lev M. Berstein},
  journal={Journal of the National Cancer Institute. Monographs},
  year={2000},
  volume={27},
  pages={
          95-112
        }
}
Estrogen exposure represents the major known risk factor for development of breast cancer in women and is implicated in the development of prostate cancer in men. Human breast tissue has been shown to be a site of oxidative metabolism of estrogen due to the presence of specific cytochrome P450 enzymes. The oxidative metabolism of 17beta-estradiol (E2) to E2-3,4-quinone metabolites by an E2-4-hydroxylase in breast tissue provides a rational hypothesis to explain the mammary carcinogenic effects… 

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